Medication

Antidepressant Discontinuation Syndrome

Related terms · Antidepressant discontinuation symptoms

Antidepressant discontinuation syndrome is a state where symptoms such as dizziness, sensory abnormalities, insomnia, and anxiety newly appear after reducing or stopping antidepressants.

Reviewed by Korean Medicine Doctor Choi Yeon-seung · Last updated 2026-08-26

Meaning and Distinctions

What is antidepressant discontinuation syndrome?

Antidepressant discontinuation symptoms may occur after dose reduction or cessation, and include dizziness, nausea, changes in sleep, sensory abnormalities, anxiety, and mood changes. The original depression or anxiety RecurrenceBecause the onset time, types of symptoms, and reactions to re-administration may differ, these must be distinguished by your prescriber. Rather than concluding on your own that symptoms are a relapse or treatment failure, keep a daily record to re-evaluate the tapering speed with your prescriber. Suicidal thoughts, severe agitation, mania, psychosis, or dizziness so severe that you cannot stand require immediate consultation with your prescriber or emergency medical care. Antidepressant discontinuation syndrome is a condition where new symptoms such as dizziness, sensory abnormalities, insomnia, and anxiety appear after reducing or stopping antidepressants.

Easily confused terms
Since it can overlap with a relapse of the original depression or anxiety, the date of dosage change is compared with the time the new symptoms began.
Why this is checked during medical evaluation
The prescriber determines whether to reduce the antidepressant dose and the speed of that reduction. Korean herbal medicine treatment does not diagnose relapse or discontinuation symptoms in place of the prescriber, nor does it provide a tapering schedule; instead, it records the temporal relationship between dosage changes and new symptoms to concurrently manage burdens on sleep, digestion, body heat, and energy levels.
What to write down for your visit
Align the medication name, last dose, any missed doses, and the dates when dizziness, electric-shock sensations, nausea, or mood changes began. Verify the current diagnosis, testing and psychotherapy stage, and the full medication list including prescriptions, over-the-counter drugs, and supplements; distinguish between original symptoms and newly emerged sensations, and track changes in sleep, heart rate, digestion, body heat, and energy levels. Pattern Identificationas well. Please write this information down with the dates and show it during your medical evaluation.

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Evidence and Update Information

The following materials were referenced to verify the basis and scope of the definitions and treatment explanations.

  1. NICE NG215: Medicines associated with dependence or withdrawal symptomsGradual reduction of benzodiazepines, Z-drugs, antidepressants, etc., and principles of individual pacing and continuous observation
Summary and review information for this page

Reviewing Medical Staff

Choi Yeon-seung, Doctor of Korean MedicineChief Director · Editor of Korean Medicine Atlas · BRC Researcher

Page Summary

Antidepressant discontinuation syndrome is a state where symptoms such as dizziness, sensory abnormalities, insomnia, and anxiety newly appear after reducing or stopping antidepressants.

What this page covers

What is explained
What should be checked first regarding the meaning of antidepressant discontinuation syndrome?
What situations are covered
Antidepressant discontinuation symptoms can occur after dose reduction or cessation and include dizziness, nausea, sleep changes, sensory abnormalities, anxiety, and mood changes.
What distinctions are made
Meaning of antidepressant discontinuation syndrome: Antidepressant discontinuation symptoms can occur after dose reduction or cessation and include dizziness, nausea, sleep changes, sensory abnormalities, anxiety, and mood changes. Because the onset time, types of symptoms, and reactions to re-administration may differ from a relapse of the original depression or anxiety, these must be distinguished by your prescriber. Rather than concluding on your own that symptoms are a relapse or treatment failure, keep a daily record to re-evaluate the tapering speed with your prescriber. Suicidal thoughts, severe agitation, mania, psychosis, or dizziness so severe that you cannot stand require immediate consultation with your prescriber or emergency medical care.
How should this be understood
Antidepressant discontinuation syndrome is a condition where new symptoms such as dizziness, sensory abnormalities, insomnia, and anxiety appear after reducing or stopping antidepressants.

Key Points

  • Meaning of antidepressant discontinuation syndrome: Antidepressant discontinuation symptoms can occur after dose reduction or cessation and include dizziness, nausea, sleep changes, sensory abnormalities, anxiety, and mood changes. Because the onset time, types of symptoms, and reactions to re-administration may differ from a relapse of the original depression or anxiety, these must be distinguished by your prescriber. Rather than concluding on your own that symptoms are a relapse or treatment failure, keep a daily record to re-evaluate the tapering speed with your prescriber. Suicidal thoughts, severe agitation, mania, psychosis, or dizziness so severe that you cannot stand require immediate consultation with your prescriber or emergency medical care.
  • Difference from similar terms: Since it can overlap with a relapse of the original depression or anxiety, the date of dosage change is compared with the time the new symptoms began.
  • Reason for verification during medical evaluation: The prescriber determines whether to reduce the antidepressant dose and the speed of that reduction. Korean herbal medicine treatment does not diagnose relapse or discontinuation symptoms in place of the prescriber, nor does it provide a tapering schedule; instead, it records the temporal relationship between dosage changes and new symptoms to concurrently manage burdens on sleep, digestion, body heat, and energy levels.

References cited on this page

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